Data privacy is a critical challenge in modern medical workflows as the adoption of electronic patient records has grown rapidly. Stringent data protection regulations limit access to clinical records for training and integrating machine learning models that have shown promise in improving diagnostic accuracy and personalized care outcomes. Synthetic data offers a promising alternative; however, current generative models either struggle with time-series data or lack formal privacy guaranties. In this paper, we enhance a state-of-the-art time-series generative model to better handle longitudinal clinical data while incorporating quantifiable privacy safeguards. Using real data from chronic kidney disease and ICU patients, we evaluate our method through statistical tests, a Train-on-Synthetic-Test-on-Real (TSTR) setup, and expert clinical review. Our non-private model (Augmented TimeGAN) outperforms transformer- and flow-based models on statistical metrics in several datasets, while our private model (DP-TimeGAN) maintains a mean authenticity of 0.778 on the CKD dataset, outperforming existing state-of-the-art models on the privacy-utility frontier. Both models achieve performance comparable to real data in clinician evaluations, providing robust input data necessary for developing models for complex chronic conditions without compromising data privacy.

Urban congestions cause inefficient movement of vehicles and exacerbate greenhouse gas emissions and urban air pollution. Macroscopic emission fundamental diagram (eMFD)captures an orderly relationship among emission and aggregated traffic variables at the network level, allowing for real-time monitoring of region-wide emissions and optimal allocation of travel demand to existing networks, reducing urban congestion and associated emissions. However, empirically derived eMFD models are sparse due to historical data limitation. Leveraging a large-scale and granular traffic and emission data derived from probe vehicles, this study is the first to apply machine learning methods to predict the network wide emission rate to traffic relationship in U.S. urban areas at a large scale. The analysis framework and insights developed in this work generate data-driven eMFDs and a deeper understanding of their location dependence on network, infrastructure, land use, and vehicle characteristics, enabling transportation authorities to measure carbon emissions from urban transport of given travel demand and optimize location specific traffic management and planning decisions to mitigate network-wide emissions.

Background Large language models (LLMs) face challenges in inductive thematic analysis, a task requiring deep interpretive and domain-specific expertise. We evaluated the feasibility of using LLMs to replicate expert-driven thematic analysis of social media data. Methods Using two temporally non-intersecting Reddit datasets on xylazine (n=286 and n=686, for model optimization and validation, respectively) with twelve expert-derived themes, we evaluated five LLMs against expert coding. We modeled the task as a series of binary classifications, rather than a single, multi-label classification, employing zero-, single-, and few-shot prompting strategies and measuring performance via accuracy, precision, recall, and F1-score. Results On the validation set, GPT-4o with two-shot prompting performed best (accuracy: 90.9%; F1-score: 0.71). For high-prevalence themes, model-derived thematic distributions closely mirrored expert classifications (e.g., xylazine use: 13.6% vs. 17.8%; MOUD use: 16.5% vs. 17.8%). Conclusions Our findings suggest that few-shot LLM-based approaches can automate thematic analyses, offering a scalable supplement for qualitative research. Keywords: thematic analysis, large language models, natural language processing, qualitative analysis, social media, prompt engineering, public health

Early detection of Alzheimer's disease (AD) is crucial because its neurodegenerative effects are irreversible, and neuropathologic and social-behavioral risk factors accumulate years before diagnosis. Identifying higher-risk individuals earlier enables prevention, timely care, and equitable resource allocation. We predict cognitive performance from social determinants of health (SDOH) using the NIH NIA-supported PREPARE Challenge Phase 2 dataset derived from the nationally representative Mex-Cog cohort of the 2003 and 2012 Mexican Health and Aging Study (MHAS). Data: The target is a validated composite cognitive score across seven domains-orientation, memory, attention, language, constructional praxis, and executive function-derived from the 2016 and 2021 MHAS waves. Predictors span demographic, socioeconomic, health, lifestyle, psychosocial, and healthcare access factors. Methodology: Missingness was addressed with a singular value decomposition (SVD)-based imputation pipeline treating continuous and categorical variables separately. This approach leverages latent feature correlations to recover missing values while balancing reliability and scalability. After evaluating multiple methods, XGBoost was chosen for its superior predictive performance. Results and Discussion: The framework outperformed existing methods and the data challenge leaderboard, demonstrating high accuracy, robustness, and interpretability. SHAP-based post hoc analysis identified top contributing SDOH factors and age-specific feature patterns. Notably, flooring material emerged as a strong predictor, reflecting socioeconomic and environmental disparities. Other influential factors, age, SES, lifestyle, social interaction, sleep, stress, and BMI, underscore the multifactorial nature of cognitive aging and the value of interpretable, data-driven SDOH modeling.

Abstract--Accurate cyclone forecasting is essential for minimizing loss of life, infrastructure damage, and economic disruption. Traditional numerical weather prediction models, though effective, are computationally intensive and prone to error due to the chaotic nature of atmospheric systems. This study proposes a machine learning (ML) approach to forecasting tropical cyclone trajectory and status using time series data from the National Hurricane Center, including recently added best track wind radii. A two-stage ML pipeline is developed: a regression model first predicts cyclone features--maximum wind speed, minimum pressure, trajectory length, and directional change--using a sliding window of historical data. These outputs are then input into classification models to predict the cyclone's categorical status. Gradient boosting regression and three classifiers--random forest (RF), support vector machine (SVM), and multi-layer perceptron (MLP)--are evaluated. After hyperparameter tuning and synthetic minority oversampling (SMOTE), the RF classifier achieves the highest performance with 93% accuracy, outperforming SVM and MLP across precision, recall, and F1 score. The RF model is particularly robust in identifying minority cyclone statuses and minimizing false negatives. Regression results yield low mean absolute errors, with pressure and wind predictions within 2.2 mb and 2.4 kt, respectively. These findings demonstrate that ML models, especially ensemble-based classifiers, offer an effective, scalable alternative to traditional forecasting methods, with potential for real-time cyclone prediction and integration into decision-support systems.

The proliferation of hate speech on social media necessitates automated detection systems that balance accuracy with computational efficiency. This study evaluates 38 model configurations in detecting hate speech across datasets ranging from 6.5K to 451K samples. We analyze transformer architectures (e.g., BERT, RoBERTa, Distil-BERT), deep neural networks (e.g., CNN, LSTM, GRU, Hierarchical Attention Networks), and traditional machine learning methods (e.g., SVM, CatBoost, Random Forest). Our results show that transformers, particularly RoBERTa, consistently achieve superior performance with accuracy and F1-scores exceeding 90%. Among deep learning approaches, Hierarchical Attention Networks yield the best results, while traditional methods like CatBoost and SVM remain competitive, achieving F1-scores above 88% with significantly lower computational costs. Additionally, our analysis highlights the importance of dataset characteristics, with balanced, moderately sized unprocessed datasets outperforming larger, preprocessed datasets. These findings offer valuable insights for developing efficient and effective hate speech detection systems.

In structure-based drug design, accurately estimating the binding affinity between a candidate ligand and its protein receptor is a central challenge. Recent advances in artificial intelligence, particularly deep learning, have demonstrated superior performance over traditional empirical and physics-based methods for this task, enabled by the growing availability of structural and experimental affinity data. In this work, we introduce DeepGGL, a deep convolutional neural network that integrates residual connections and an attention mechanism within a geometric graph learning framework. By leveraging multiscale weighted colored bipartite subgraphs, DeepGGL effectively captures fine-grained atom-level interactions in protein-ligand complexes across multiple scales. We benchmarked DeepGGL against established models on CASF-2013 and CASF-2016, where it achieved state-of-the-art performance with significant improvements across diverse evaluation metrics. To further assess robustness and generalization, we tested the model on the CSAR-NRC-HiQ dataset and the PDBbind v2019 holdout set. DeepGGL consistently maintained high predictive accuracy, highlighting its adaptability and reliability for binding affinity prediction in structure-based drug discovery.

Augmented reality (AR) systems are increasingly deployed in tactical environments, but their reliance on seamless human-computer interaction makes them vulnerable to cognitive attacks that manipulate a user's perception and severely compromise user decision-making. To address this challenge, we introduce the Perception Graph, a novel model designed to reason about human perception within these systems. Our model operates by first mimicking the human process of interpreting key information from an MR environment and then representing the outcomes using a semantically meaningful structure. We demonstrate how the model can compute a quantitative score that reflects the level of perception distortion, providing a robust and measurable method for detecting and analyzing the effects of such cognitive attacks.

--Mobile Large Language Models (LLMs) are revolutionizing diverse fields such as healthcare, finance, and education with their ability to perform advanced natural language processing tasks on-the-go. However, the deployment of these models in mobile and edge environments introduces significant challenges related to privacy and security due to their resource-intensive nature and the sensitivity of the data they process. This survey provides a comprehensive overview of privacy and security issues associated with mobile LLMs, systematically categorizing existing solutions such as differential privacy, federated learning, and prompt encryption. Furthermore, we analyze vulnerabilities unique to mobile LLMs, including adversarial attacks, membership inference, and side-channel attacks, offering an in-depth comparison of their effectiveness and limitations. T o bridge this gap, we propose potential applications, discuss open challenges, and suggest future research directions, paving the way for the development of trustworthy, privacy-compliant, and scalable mobile LLM systems. The advent of mobile Large Language Models (LLMs) represents a significant milestone in the evolution of AI, enabling advanced natural language processing capabilities to be deployed in mobile and edge environments [1]-[3]. By bringing powerful AI tools closer to end-users, mobile LLMs are revolutionizing industries such as healthcare [4], finance [5], and education [6] with real-time, on-device applications.

Subjective language understanding refers to a broad set of natural language processing tasks where the goal is to interpret or generate content that conveys personal feelings, opinions, or figurative meanings rather than objective facts. With the advent of large language models (LLMs) such as ChatGPT, LLaMA, and others, there has been a paradigm shift in how we approach these inherently nuanced tasks. In this survey, we provide a comprehensive review of recent advances in applying LLMs to subjective language tasks, including sentiment analysis, emotion recognition, sarcasm detection, humor understanding, stance detection, metaphor interpretation, intent detection, and aesthetics assessment. We begin by clarifying the definition of subjective language from linguistic and cognitive perspectives, and we outline the unique challenges posed by subjective language (e.g. ambiguity, figurativeness, context dependence). We then survey the evolution of LLM architectures and techniques that particularly benefit subjectivity tasks, highlighting why LLMs are well-suited to model subtle human-like judgments. For each of the eight tasks, we summarize task definitions, key datasets, state-of-the-art LLM-based methods, and remaining challenges. We provide comparative insights, discussing commonalities and differences among tasks and how multi-task LLM approaches might yield unified models of subjectivity. Finally, we identify open issues such as data limitations, model bias, and ethical considerations, and suggest future research directions. We hope this survey will serve as a valuable resource for researchers and practitioners interested in the intersection of affective computing, figurative language processing, and large-scale language models.